Research Paper

Comparison Of Sequential Therapy And Standard Triple Therapy For The First-line Eradication Of Helicobacter Pylori

Abstract :

Background: Helicobacter pylori is a major cause of gastric diseases. Some studies in Iran showed that the resistance rate to clarithromycin was in the range of 5% to 45.2% .The present study aimed at evaluating the efficacy of a sequential therapy versus standard triple therapy in eradication of H.pylori infection. Methods: Patients with positive histopathological h.pylori infection were randomly allocated into three groups. All endoscopies were performed with FUJINON by two expert gastroenterologist. The first group received omeprazole 2x20 mg and amoxicillin 2x1 g per day for first week and omeprazole 2x20 mg, metronidazole 2x500 mg and clarithromycin 2x500 mg per day for second week (regimen A).The second group received the same treatment in first week but clarithromycin was replaced by levofloxacin 2x500 mg per day in second week (regimen B). And the last group received omeprazole 2x20 mg, amoxicillin 2x1 g and clarithromycin 2x500 mg per day for two weeks (regimen C). Results: 294 patients completed the study and underwent 13C-UBT at the sixth week. Eradication rates of 87.7% in sequential levofloxacin based (B) and 76.5% were achieved in the clarithromycin-based (A) and 67.3% in standard triple therapy(C). According to this study, only therapeutic intervention in group B has the effect on H pylori eradication. Conclusion: Over the past decade, eradication programs regarding H. pylori-related diseases have been based on standard triple therapy worldwide. Present study show sequential levofloxacin based therapy for eradication of helicobacter pylori was more effective than sequential clarithromycin based and standard triple therapy.

Cite This Article :

Article :