Original Research Paper

Incidentally Diagnosed Disseminated Histoplasmosis Among Non Hiv Patients Of South Asian Region.

Abstract :

Background Histoplasmosis is a soil based rare air borne fungal infection and mostly documented in HIV positive patients. They are common in people living near valley region. Materials and methodsThis is a multiinstitutional study. We report 3 cases of asian women from different regions of Southern Rajasthan who died due to delayed diagnosis of Histoplasmosiswithin few days of admission. They all had complaints of fatigue and fever since 1 month. One presented with decreased urine output and pancytopenia. Others had complaints of prolonged fever with pancytopenia and fatigue. All were diagnosed on Bone marrow examination for presence of Histoplasma Capsulatum, diagnosis was supported by special stains used for reporting. Treatment was started but patients deteriorated and died within 10 days of admission.Conclusion- Delay in diagnosis of Histoplasmosis leads to death of patients. So, Histoplasmosis is considered as a differential diagnosis of prolonged fever with pancytopenia and chronic infections.

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