Original Research Paper
Is There A Direct Relationship In Spike Glycoprotein Percent Identity, Peptide Count, And Mortality Rate Between Daughter Human Coronavirus Strains And The "parent" (hcov-229e)?
Ebrahim Waleed Ebrahim Ahmed Al Mansoori, Hamdan Mohamed Khalfan Khairi Al Noobi Al Hammadi, Mohammed Abdalla Rashid Abdalla Rashid
In this investigation, we sought to identify the following relationships between the Human Coronavirus HCoV-229E strain (Parent) and subsequent daughter strains (HCoV-NL63, HCoV- HKU1, HCoV-OC43, MERS-CoV, SARS-CoV, and SARS-CoV2) in their Spike Glycoproteins: Percent Identity, Peptide Differences, and Mortality Rate. We also aimed to propose a possible reason as to why a given strain of Human Coronavirus is more fatal than others. To compare percent identity between each daughter strains Spike glycoprotein sequence to that of the Parent, we used an online amino acid sequence alignment database called Protein BLAST. To identify peptide-count differences between Parent and daughter Human coronavirus strains Spike Glycoprotein sequences, we used an online protein classification database called InterPro. To compare mortality rates between each Human coronavirus strain, we used several online science websites and journals, including the World Health Organization, to obtain reliable data. During our analysis, we determined that no direct relationship exists between low or high percent Spike Glycoprotein sequence identity and mortality between daughters and parent.That is, if a daughters sequence was closer to that of the Parent, it did not mean that its mortality rate would be similar. We also learned that there is no direct relationship between a high or low number of additional peptides found on the Spike Glycoprotein of daughter strains and their mortality rate, as compared to the Parent. Meaning, strains having similar peptides to that of the Parent were not similarly fatal. We learned that Daughter Four (MERS-CoV) has the highest mortality rate among all the other human Coronavirus strains, possibly due to the presence of three unique peptides.
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