Original Research Paper
Evaluation Of Thrombolytic Potential Of Some Common Spices Available In Bangladesh
Fatema Tabassum, Md. Imran Nur Manik, Furhatun Noor, Mohammad Taleb Hossain, Api Majumder, Abu Zobayed
Herbal medicinal products have been recognized as an important source for discovering new pharmaceutical molecules that have been used to treat different diseases. Numerous plant species have been reported to have pharmacological activities attributable to their phytoconstituents such are glycosides, alkaloids, flavonoids, saponins, steroids, tannins, terpenes, etc. The present study was designed to investigate the comparative study of the thrombolytic activity of the aqueous and ethanolic extract of some common spices available in Bangladesh were determined. From our study we have found that the clot lysis activity of aqueous extract of Fenugreek, Fennel, Chili, Coriander, Clove and Cinnamon showed 11.59%, 14.53%, 29.61%, 3.13%, 11.95% and 8.56% and the ethanolic extracts of the same spices possessed 3.18%, 6.20%, 23.51%,4.07%,16.55% and 19.93% respectively and they showed significant % of clot lysis effect with reference of streptokinase (51.06%%) and water (2.27%). It is concluded that the in-vitro thrombolytic activity showed by the plants were due to the presence of these phytochemicals. Further studies are highly needed for further drug development.
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