Research Paper
Role Of High Mobility Group Chromosomal Protein 1 And Clusterin As Markers In Patients With Hepatitis C Virus Related Hepatocellular Carcinoma
Mahmoud Mahmoud M. Abu Elanien Khattab, Fatma Alzahraa Sayed Bukhary, Mohamed Alsayed Abd Alaal Shatat, Lamiaa Hamdy Aly, Fatma Mokhtar Saban
CLUSTERIN is A highly conserved heterodimeric disulfide-linked 80K glyco- protein originally named apolipoprotein-J (ApoJ) , which is widely distributed in tissues and body fluids. In 1983 identified a high-molecular weight protein in ram rete testis fluid and named Clusterin CLU because it is a cell-aggregating factor capable of eliciting the Clustering of Sertoli cells . In humans, it was firstly purified from serum and the cloned gene was named CLI (complement cytolysis inhibitor) or ApoJ due to similarities with other known. It consists of two polypeptide chains connected by four to five disulfide bonds.
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