Original Research Paper
Drug utilization pattern of antiepileptic drugs and their adverse effects in pediatric population in Santosh medical college, Ghaziabad, U.P.
Dr. Anjar Ahmad, Prof. Dr. Mohammad Zakiuddin
BACKGROUND: Epilepsy is a condition characterized by recurrent (two or more) seizure, unprovoked by any immediate identified cause. The desired outcome of antiseizure drug (ASD) therapy is to be seizure-free throughout the rest of life. Antiepileptic drugs (AEDs) are also commonly used therapy for other conditions like prophylaxis for a manic depressive disorder, to relieve neuralgic pain and for many more conditions apart from epilepsy. AIMS AND OBJECTIVE: The objective was to study the utilization pattern and adverse drug reactions (ADRs) associated with the use of ASDs in pediatric outpatients in epilepsy clinic. Present study was performed with an aim to study the utilization pattern of anti-epileptic drugs (AEDs) for the pediatric patients suffering from various forms of epileptic seizures.MATERIAL AND METHODS: This prospective, longitudinal study was conducted for a period of eight months in Pediatric Neurology Department of a tertiary care teaching hospital. The data collected from 50 children at the end of the study, were compiled in a specially designed data form and were analyzed. RESULT: The distribution of pediatric seizures was found to be high in male children (62%) and in the age group of 2 to 5 years (46%). The majority of the children (70%) were diagnosed with Generalized Tonic-clonic seizures. Sodium valproate was the commonly prescribed AED in all forms of seizures followed by Carbamazepine (18%), Phenobarbitone (4%) and Phenytoin Sodium (4%). AEDs were mostly prescribed as Monotherapy (82%). An adverse reaction noted during this study was minimal (12%). CONCLUSION: Sodium valproate, a conventional AED still remains the commonly prescribed AED for all types of seizures in children aged 2 to 16 y and also was found to be effective and safe.
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