Original Research Paper

Unusual Clinical Manifestations And Outcome Of Multisystem Inflammatory Syndrome In Children (mis-c) In A Tertiary Care Hospital Of North India

Dr. Akhilesh Kumar Ram

Abstract :

Till date, there is paucity of published literature on clinical manifestations of Coronavirus disease 2019 (COVID-19) in children from low-middle-income countries (LMIC). Most of the reports are from Europe, USA or China. Our study aimed to capture data on varied and unusual clinical presen- tation and management of MIS-C (Multisystem Inammatory Syndrome in Children) with COVID-19 and compare the MIS-C and non-MIS-C children. This was a single-centre cohort study of 41 COVID positive children 012 years age hospitalized between 1 April 2020 and 31 July 2020. Data were entered into standardized WHO Case Report Form and analysed using strata 15.0 statis- tical software. Twenty out of 41 children fullled the criteria of MIS-C. Male-to-female ratio in the cohort was 1.73:1. In MIS-C cases, predominant clinical manifestation was fever (100%), neuro- logical manifestations (80%), lower respiratory tract infection (50%), rash (35%) and acute gastro- enteritis (25%). They were categorized into Acute Encephalitis-like illness in 35%, Kawasaki-like dis- ease, Toxic Shock-like syndrome and Comorbidity with systemic complications in 20% each. Ninety percent of MIS-C cases required oxygen supplementation with odds ratio (OR) 18 (3.22100.48), whereas 65% required mechanical ventilation with OR 37.14 (4.08338.10). Most of them had raised inammatory markers and hepatic enzymes derangement. Steroids, Intravenous immuno- globulin and supportive therapy were mainstay of management for MIS-C group. Most MIS-C group children had multisystem involvement with predominant neurological manifestations at time of presentation. Delay in diagnosis and referral may have adversely affected the prognosis and outcome.

Cite This Article :

UNUSUAL CLINICAL MANIFESTATIONS AND OUTCOME OF MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) IN A TERTIARY CARE HOSPITAL OF NORTH INDIA, Dr. Akhilesh Kumar Ram, INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH : Volume-5 | Issue-12 | December-2020

Article :

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