Original Research Paper

Ondansetron Versus Low Dose Ketamine In Subarachnoid Block Induced Hypotension And Shivering - Which Is Better?

Abstract :

Back ground: subarachnoid block (SAB) is a safe anesthestic technique commonly practiced in world wide. However it is associated with hypotension (33%), bradycardia (13%) and shivering whish are due to hypovolemia, sympathetic blockde and Bezold- zarisch reflexthrough intracardiac serotonin (5HT3) receptors and vagus nerve.Objective: The aim of the study was to evaluate the efficacy of Ondansetron versus low dose Ketamine in prevention of hypotension and shivering during subarachnoid block.Methods: 120 patients scheduled for elective surgeries were randomly allocated in to two groups. 5 min before induction of subrachnoid block group O (n=60) received 4 mg of Ondansetron and group K (n-60) received 0.25 mg/kg Ketamine intravenously. HR, MAP,shivering , bromage scale and sedation were assessed every 5 min after SAB.Results: decreases in HR significantly lower in group K than in group O after SAB, 2, 8, 15, 25 and 40 min (P 0.001). Decrease in MAP was significantly lower in group K than in group O. Conclusion: Administration of intravenous ondansetron and ketamine prior to SAB prevents the drop in heart rate,MAP, and also prevents intraoperative shivering effectively.

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