Research Paper

Neutrophils Cd11b Expression As Biomarker In The Early Diagnosis Of Neonatal Sepsis.

Abstract :

Objective: we aimed to assess the value of neutrophils CD11b for the early diagnosis of neonatal infection and its relation with other laboratory marker as hematological and CRP.Design: the study was conducted among newborns hospitalized for rule out of sepsis to neonatal intensive care unit (NICU) .1-Subjects and setting: a total of 90 newborns [30 neonates with proven sepsis clinically and positive blood culture (patients group),30 clinical symptoms of sepsis and negative blood culture and may negative CRP(suspected group) and 30 healthy newborns(control group)] were enrolled in the study. On admission to NICU ,blood was sampled for CRP, complete blood count (CBC), blood culture and CD11b marker before starting antibiotic therapy .Results In this study, at a cut off level of CD11b was 17.8, the sensitivity was 98.33%,the specificity was 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) was 96.77%.And CRP, the sensitivity was 76.7%, the specificity was 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) was 68.2%.CD11b was elevated in patients group compared to the control group.Conclusion: Measurement of CD11b as a marker on surface of blood neutrophils can be useful for diagnosis of neonatal sepsis in the early phase.

Cite This Article :

Article :