Research Paper

Pathophysiology Of Spinal Cord Injury And Effect Of Polyunsaturated Fatty Acids

Abstract :

The purpose of this paper is to review the current literature regarding the pathophysiology of spinal cord injury and effects of polyunsaturated fatty acids in that injury. Different types of polyunsaturated fatty acids affect differently in spinal cord injury. -3 fatty acids decrease the injury and improve the functional outcome. In contrast -6 fatty acids aggravate the injury and worsen the outcome. Although research regarding spinal cord injury remains limited, pathophysiology of spinal cord injury and effects of -3 and -6 fatty acids including mechanism of action through which they produce these effects in that injury were reviewed in this paper with available current literature. Most of the studies regarding spinal cord injury were done in animals. So, further studies should be conducted to know and prove these effects of the polyunsaturated fatty acids in spinal cord injury in human trials in future.

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