Evaluation of serum level of micro RNA 224 in patients with hepatocellular carcinoma.
Nady Mahmoud Semeda, Madiha Mohammed Ahmed Makhlouf, Mohammed Abdel Hameed Ahmed, Hala Ibrahim Mohammed, Zeinab Mostafa Saad
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, and the third most common cause of cancer-related death that kills more than 650,000 people around the world each year. HCV causes HCC mainly through continuous inflammation and hepatocyte regeneration in the setting of chronic hepatitis and subsequent progression to cirrhosis, which is thought to lead to chromosomal damage and possibly to initiate hepatic carcinogenesis. The regulation of miRNAs on their target genes is mainly negative. It is reported that about half of human miRNAs localized in fragile chromosomal regions, which are associated with the onset of various human cancers, indicating that miRNAs are crucial in cancer development and progression.
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