Research Paper

The Clinical Use Of The Urinary G1 Cell Cycle Arrest Biomarker { Timp-2} For Early Prediction Of Acute Kidney Injury In Critically Ill Children

Abstract :

Background Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences , and its incidence is rising at an alarming rate . Tissue inhibitor of metalloproteinase-2 (TIMP-2) was reported as an emerging biomarker for predicting severe AKI in critically ill patients Methods This Prospective case control studywas conducted on 60 critically illchildren of both sex admitted to PICU of Benha children Hospital and 20 healthy control group of both sex. The study was conducted during the period from September 2016 to December 2016 . All cases were followed up for 2 months or until they improved or died. The study group was devided into 3 groups Acute kidney injury group (AKI gp) : critically ill with AKI included 36 patients , Non Acute kidney injury group(Non AKI gp) : critically ill without AKI included 24 patients , Control group : control group comprised 20 apparently healthy children matched in age and sex with patient groups . AKI etiologies were: dehydration/hypovolemia (n = 5) , hemodynamic instability (n = 9), septic shock (n =20) vasculitis (n= 2) Results There was statistical significant difference between the studied groups regarding serum TIMP 2 day 1 as it was higher in AKI group than non AKI group than control group Conclusions TIMP-2 can be used as a urinary biomarker for early detection of acute kidney injury (AKI) in critically ill patients .

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