Original Research Paper

The Spectrum Of Clinical Profile, Comparison Between Different Criteria And Outcome In Hla B51 Positive South Indian Behcet's Patients A Retrospective Tertiary Centre Study

Divya Y, Rajeswari S, Balaji C, Saranya C, Aishwarya R

Abstract :

The diagnostic utility of HLA B51 (Human Leukocyte Antigen) in association with Behets disease(BD) has been identified. However, the clinical manifestations of HLA B51 positive patients who have not satisfied the criteria for Behcets have been rarely reported. Our objective was to study the clinical profile of HLA B51 positive patients and to include them under the spectrum of International criteria for Behcets disease (ICBD) and the modified Japanese criteria, and also to study the outcome in these patients. This is a retrospective prospective observational study conducted over 3 years (2018-2021) in HLA B51 positive patients. The clinical presentations, treatment given and follow up response to treatment were observed. In the study cohort of 28 HLA-B51 positive patients, mean age was 41.7 years. 17 (60.7%) had oral ulcers, 5 (17.8%) genital ulcers, 7 (25%) skin lesions, 11 (39.2%) had Pathergy positivity, 19 ( 67.8%) ocular, 7 (25%) neurological, 3 (10.7%) Gastro-intestinal (GI) and 3(10.7%) had vascular manifestations.12 (42.8%) satisfied ICBD criteria and 2 (7%) satisfied Japanese criteria for BD. 15 (53.5%) were given immunosuppressant therapy with [Azathioprine (AZA) in 10(35.7%), Mycophenolate mofetil (MMF) in 4(14.2%) and cyclophosphamide (CYC) in 1(3.5%)]. Biologics were given in 7 (25%) with [Adalimumab(ADA) in 6(21.4%) and Rituximab (RTX) in 1(3.5%)]. Our study showed female predominance, with more ocular manifestations , oral aphthous ulcers and less gastrointestinal involvement. Azathioprine (AZA) showed better response compared to Mycophenolate mofetil (MMF).

Keywords :

BD   CNS   CVS   GI   HLA B51   

Cite This Article :

THE SPECTRUM OF CLINICAL PROFILE, COMPARISON BETWEEN DIFFERENT CRITERIA AND OUTCOME IN HLA B51 POSITIVE SOUTH INDIAN BEHCET'S PATIENTS A RETROSPECTIVE TERTIARY CENTRE STUDY, Divya Y, Rajeswari S, Balaji C, Saranya C, Aishwarya R, INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH : Volume-9 | Issue-7 | July-2024

Article :

View PDF Article No. : 1Number of Views : 846