Original Research Paper
Potential Biochemical Markers In Covid-19 Patients.
Thejaswini Mupalla, Surya Tiwari, Pallavi Tiwari, Akanksha Dubey
The COVID-19 pandemic has indeed caused a global health crisis, and India is no exception to its impact. The country has been struggling to control the spread of the virus due to factors such as overpopulation, lack of awareness, and a weak healthcare system. The pandemic has also affected the Indian economy and development. COVID-19 primarily affects the respiratory system, but it can also have an impact on other organs such as the liver, kidneys, heart, and pancreas. Studies have shown that COVID-19 patients may present altered laboratory parameters, which can be used as biomarkers to assess the progression of the disease and categorize patients with severe and/or fatal clinical conditions. In COVID-19 patients, liver injury is a common finding and is associated with a worse prognosis. Elevated liver enzymes such as ALT and AST are frequently seen in COVID-19 patients, indicating liver damage. Similarly, renal impairment is also common, and elevated serum creatinine and blood urea nitrogen levels have been observed in severe cases. Cardiac injury is another significant complication of COVID-19 and can lead to arrhythmias, myocarditis, and heart failure. Elevated levels of cardiac biomarkers such as troponin, NT-proBNP, and CK-MB have been reported in COVID-19 patients with severe disease. Pancreatic injury in COVID-19 patients is also being increasingly recognized. Elevated levels of pancreatic enzymes such as amylase and lipase have been observed, indicating pancreatic inflammation and injury. Markers of inflammation such as CRP, IL-6, and ferritin have been found to be elevated in COVID-19 patients, and their levels correlate with disease severity. These markers can help predict which patients may progress to a severe clinical condition and require more aggressive management. In conclusion, COVID-19 can have significant impacts on various organ systems in the body, and monitoring altered laboratory parameters and biomarkers can aid in the early detection and management of complications associated with the disease.
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