Original Research Paper

Study Of Glycated Hemoglobin In Diabetes Mellitus And Its Association With Dyslipidemia

Abstract :

IntroductionDiabetes mellitus is a metabolic disorder characterized by the hyperglycemia and disturbance of carbohydrate, lipid, and protein metabolism due to insulin resistance or relative insulin deficiency. Patients with type 2 Diabetes mellitus have an increased prevalence of dyslipidemia, which contribute to their high risk of cardiovascular disease (CVDs). A timely intervention to normalize the circulating lipids could reduce the chances of cardiovascular complications. Glycated hemoglobin (HbA1c) is an indicator of glycemic status over long term. Many studies have proposed, HbA1c to be used as biomarker of both glycemic control and dyslipidemia in type 2DM.Materials and MethodsA total of 100 patients with Type 2 DM were included in this study. The whole blood and sera were analyzed for fasting blood sugar (FBS), HbA1c, total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Dyslipidemia was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Diabetes was defined as per American Diabetes Association criteria. The correlation of FBS, HbA1c with lipid ratios and individual lipid indexes were analyzed. The statistical analysis was done by SPSS statistical package version 20.0. ResultThere was significant association of HbA1c with dyslipidemia as per Chi-Square test. HbA1c was found to have significant positive correlation with Total Cholesterol, Triglycerides and LDL and significant negative correlation with HDL and HDL/LDL ratio. The mean TC, TG, LDL was significantly lower and HDL and HDL/LDL was significantly higher in patients with good glycemic control.Conclusion: This study suggests utility of HbA1c as a marker of dyslipidemia in addition to chronic hyperglycemia and hence should be analyzed accordingly and thus early diagnosis of dyslipidemia can be used as a preventive measure for the development of CVD in patient type 2 diabetes mellitus.

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