Original Research Paper

Amebicide Agents: Luminal Amebicides, Systemic Amebicides And Mixed Amebicides

Abstract :

Amebiasis can be considered as acute or chronic, which contrasts degrees of illness, from no sign and symptoms to mild diarrhea to fulminating dysentery. A pathogenic parasite called Entamoeba histolytica is present in the intestine of human beings and multiple other animals. Entamoeba histolytica inhabits in the mucous and sub-mucous layers of large intestine. Mixed amebicides are highly active against on both the luminal and systemic forms of the disease, however luminal accumulations are too less for single-medicine management. Metronidazole is one of the blueprinted medicines for the management of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. Metronidazole has a cytotoxic activity on facultative anaerobic bacteria such as helicobacter pylori and gardnerella vaginalis, but how metronidazole acts on these pathogens is unknown; however it rupture of DNA secretion as well as nucleic acid secretions/metronidazole diffuses into the microorganism to suppresses protein secretions by interacting with DNA and causing injury of helical DNA structure and strand cascading. Tinidazole is a nitroimidazole identical to metronidazole and is initiated intracellularly by bacterial or parasitic enzymes to a radical anion, which detriments high protein molecules and deoxyribonucleic acid. Diloxanide furoate is considered as a safe and effective medicine for the management of asymptotic or symptomatic persons who are passing cysts of entameba histolytica.

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