Original Research Paper

A Comparative Evaluation Of Oral Melatonin, (i.v) Dexmedetomidine And Combination Of Both For Attenuation Of Haemodynamic Responses To Laryngoscopy And Intubation In Middle Ear Surgery

Abstract :

Introduction : Airway management is the evaluation, planning, and use of medical procedures and devices for the purpose of maintaining or restoring ventilation in a patient. Endotracheal intubation is required to provide a patent airway when patients are at risk for aspiration, when airway maintenance by mask is difficult, and for prolonged controlled ventilation. This research aimed to investigate the impact of Melatonin with Dexmedetomidine in mitigating cardiovascular responses to laryngoscopy and endotracheal intubation in candidate in cases supporting voluntary operation. Aim and Objective: To compare the role of Oral melatonin with (i.v) Dexmedetomidine alone and in combination of both for attenuation of haemodynamic responses during Laryngoscopy and intubation and compare the effect on haemodynamics.Methods and methods: This study was a randomized prospective double blinded study conducted in Department of Anaesthesiology and Critical Care, MLB medical College, Jhansi (UP) in patients posted for elective middle Ear surgeries during the period March 2018 to October 2019, minimum 150, patients were selected for the study.Result and Conclusion: Mean Heart Rate and Mean Systolic blood pressure was more stable and showed less variation from baseline heart rate value in group 3 patients (Melatonin and Dexmedetomidine combination) was more stable and showed less variation from baseline Systolic blood pressure value in group 3 patients. Mean Arterial saturation (SpO2) is >95 % in group 1, group 2 and group 3 patients, and in group 2 , there were 6 cases reported where arterial saturation ( SPO2) falls below 95% and 3 cases were reported where arterial saturation falls below 92% which is supplemented by oxygen, after iv infusion of study drug (Dexmedetomidine 1 g/kg). It can be therefore be concluded that- Both Melatonin (6mg) and Dexmedetomidine (1g/kg) can attenuate the haemodynamic changes during laryngoscopy and intubation.

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