The healing effects of hydroalcoholic extract of Hypericum perforatum on experimental corneal injury in rabbit
Mehdi Ghahramanifar, Bahman Sharifi, Masoud Haghani, Ali Ghadimi Moghadam, Hossain Sadeghe, Hebatollah Sadeghe, Abdolkarim Ghadimi Moghadam
Background: corneal alkali injury is one of the most important of eye defects. An epithelial recovery is the most important issue, so drug therapy is essential to facilitate epithelialization again. Methods: The corneal ulcer induced by NaOH on rabbits eye. Animals were randomly divided into 7 groups of 7 including, sham group, betamethasone, chloramphenicol, negative control group, 1 mL of 1%, 2% and 4% H. perforatum extract respectively. On day-2, the tissue samples of aqueous humor and vitreous humor were obtained from rabbits eye. Results & Conclusion: The aqueous humor concentration of MDA and NO, corneal inflammation and edema in therapeutic groups that receiving the H. perforatum extract at doses of 2 and 4% especially at dose of 4%, were lower than that of negative control group. In conclusion the extract had healing effects in corneal ulcer possibly due to antioxidant and anti-inflammatory effects.
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