Original Research Paper

Electroencephalographic Pattern And Other Determinants Of Seizure Freedom In Idiopathic Generalized Epilepsy With Generalized Tonic Clonic Type Of Seizures In Children.

Abstract :

Background: Patients with idiopathic generalized epilepsy have varied response to antiepileptic drugs. Determinants of seizure freedom in Idiopathic generalized epilepsy with generalized tonic-clonic type of seizure in children was least studied. We sought to determine few clinical and EEG pattern associated with poor control of seizure.Methods: We retrospectively studied risk factors including EEG pattern by classifying it in the atypical abnormal, Typical abnormal, normal in pediatric patients less than 12 years with idiopathic generalized epilepsy having generalized tonic-clonic type of seizures from the onset of epilepsy. Relationship between risk factor and seizure freedom were analyzed.Result: 126 patients were included, with male: female ratio 1.1:1, with a median age of 5 years. 69 % patients had good control seizure. 57.1% had age at onset less than 6 year, 15.9% had family history of epilepsy, and both were risk factor for poor control of seizure with p-value 0.039, 0.0021 respectively. Most patients had typical abnormal EEG pattern (39.7%), followed by atypical abnormal pattern (36.5%). Atypical abnormal pattern in EEG was a determinant of poor control of seizure. (p-value: 0.0003).Conclusions: Majority of children attained seizure freedom with appropriate anti-epileptic drugs. Atypical abnormal pattern in EEG, early onset and family history of epilepsy are associated with poor seizure freedom.

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