Clinical pattern of Rotavirus Infection in diarrhea cases from Navi Mumbai: Focus on symptoms not considered for Vesikari scoring
Kshitija Rane, Pankhuri Nakul Kothari, Nimain Charan Mohanty, Mansi Kapil Thakur, Girish Kishor Pai, Dattatraya Shankar Joshi, Anant Dattatraya Urhekar, Nitin Nanasaheb Kadam
Introduction: Rotavirus diarrhea has been highest threat to neonates and toddlers all over the world. India contributes highest percentage with few other developing countries from Asia and South Africa. Hypermutability of the virus is due to reassortment of segmented genome which leads to generation of new recombinant genotypes. Continuous screening of pathology and clinical symptoms of rotavirus diarrhoea is inevitable to completely eradicate the disease. Study design: Proposed prospective observational study involved total 207 patients. Children less than 5 years showing symptoms of acute diarrhea were examined and standardized. Proforma was used to collect the demographic and clinical profile of the children. Severity of the illness was classified as per Vesikari scoring system and the dehydration was treated as per WHO protocol. Stool samples were collected and tested for rotavirus infection. Results: In the present studies, 207 cases of diarrhoea were screened for rotavirus infection of which 22 were found positive (10.62%) by technique of electropherotyping. Disease pattern comparison between rotavirus positive and negative groups showed some remarkable parameters associated with incidence rotavirus diarrhea such as, mean age, stool consistency, lethargy, vitamin deficiency and hospitalization. Seasonal variation in case of rotavirus infection remains unresolved. Conclusions: Data from present study highlights current scenario of clinical pattern and disease pathology for rotavirus infection induced pediatric diarrhoea in Navi Mumbai and Raigad region.
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