Research Paper

Effects Of Dexmedetomidine On Attenuation Of Hemodynamic Changes During Laparoscopic Surgeries

Abstract :

BACKGROUND: Dexmedetomidine has been shown to provide good perioperative hemodynamic stability with minimum alveolar concentration sparing effect on inhalational anesthetic agents during laparoscopic surgeries performed under general anesthesia.AIM:This study was aimed to investigate the effects of dexmedetomidine on attenuation of hemodynamic changes and requirements of intra operative analgesic and inhalational anaesthetic during laparoscopic surgeries and its postoperative side effects. MATERIALS &METHODS : 70 Patients were recruited and dived into two groups Group D: Dexmedetomidine ( n-35 ) Receive bolus dose of dexmedetomidine 1mcg/kg,over 10 minutes followed by continuous infusion of the same at the rate of 0.5 mcg/kg/hrGroup S: Saline (n-35 ) same infusion rate.Herat rate systolic blood pressure diastolic blood pressure were measured at baseline, After loaing dose, After intubation , 20 mins after pneumoperitoneum, 60 mins after pneumoperitoneum, After extubation. And Post operative pain. RESULTS: Intra operative mean HR and mean BP in GROUP D were lower than GROUP S throughout the laparoscopy surgery. Requirement of intra operative fentanyl, inhalational agent and post operative analgesic were significantly more in GROUP S compared to GROUP D. Significant nausea and vomiting were noted in GROUP S. CONCLUSION: Dexmedetomidine as an adjuvant in general anaesthesia for laparoscopic surgeries provided a stable hemodynamic profile in the perioperative period and effectively blunted pressor response to intubation and extubation, leading to minimal requirement for additional analgesics and potent inhalational agents.

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