Relationship Between Serum Free T4 And Thyroid Stimulating Hormone Levels In Preterm Neonates And Respiratory Distress Syndrome
Mohamed Mohamed El Mazahy, Lotfy Abd Alfattah Al Sehaimy, Mahmoud Farag Salem, Alshaymaa Mohamed Mohamed Hamad
Background and objectives: Worldwide 15 million babies are born preterm every year. Preterm birth is one of the leading causes of neonatal morbidity and mortality worldwide. Respiratory distress syndrome (RDS) is one of the most common respiratory complications of prematurity and its incidence inversely proportional to gestational age and birth weight. Despite the proven efficacy of antenatal corticosteroids in preventing RDS, they are not effective at preventing all cases of RDS and are limited by the time required to exert an effect on lung maturation and surfactant production before preterm birth. So the use of thyroid hormones has the potential to stimulate surfactant release and reduce respiratory morbidity in preterm infants with RDS. Methods: In This In case control study we measure the serum free thyroxin (FT4), and thyroid stimulating hormone (TSH) in 60 preterm neonates in Al-Azhar University Hospital in New Damietta during 1st postnatal 24 hours to demonstrate the relationship between their levels and RDS. Results: We found in this study that there was no relation between TSH serum levels and both the occurrence and the severity of RDS, however; there was a significant negative correlation between FT4 serum levels and both the occurrence and the severity of RDS. The study also revealed significant decrease in FT4 in the RDS subgroup with lower gestational age compared to the RDS subgroup with higher gestational age. Conclusion: There is significant negative correlation between the occurrence and severity of RDS and the serum level of free thyroxin (FT4) but there is no correlation between the occurrence and severity of RDS and the serum level of thyroid stimulating hormone (TSH) in preterm neonates.
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