Research Paper
Value Of Urinary Kidney Injury Molecule-1 Level As A Marker Of Nephropathy In Hypertensive Patients
Mahmoud Hassan S Khedr, Eglal M. S Hamed, Safaa M. H. Ali, Hend M. Moness, Eman S. Mohamed
Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion which is expressed at very low level in normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury and can be detected in urine(8). Plasma KIM-1 level also can specically reects acute and chronic kidney injury(9). Tissue KIM-1 expression is one of the best predictor of kidney function(10). Urinary KIM-1 levels reect tissue KIM-1 and is associated with inammation and renal function loss(11). It has been shown to be a good predictor of renal injury prior to detectable changes in eGFR(12). Thus, it can be used as a sensitive, noninvasive, and quantitative biomarker for diagnosis and monitoring of kidney injury.
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